Hyalgan is a sterile mixture that is made up mostly of a natural, idly purified sodium hyaluronate that comes from rooster combs. Hyaluronate is a natural chemical found in the body and is present in high amounts in joint tissues and in the fluid that fills the joints. The body's own hyaluronate acts like a lubricant and a shock absorber in the joint, and is needed for the joint to work properly. In osteoarthritis there may not be enough hyaluronate, and there may be a change in the quality of the hyaluronate in joint fluid and tissues.

Hyalgan is used to relieve the pain due to osteoarthritis. It is used for patients who do not get adequate relief from simple painkillers or from exercise and physical therapy.

If you have osteoarthritis, there are several things you can do that do not involve Hyalgan injections. These include the following:

Non-drug treatments

  •          avoiding activities that cause excess pain in your joints
  •          exercise
  •          physical therapy

Drug therapy

  •          painkillers such as acetaminophen and narcotics
  •          drugs that reduce inflammation such as aspirin and other nonsteroidal anti-inflammatory agents such as ibuprofen and naproxen
  •          corticosteroids that are injected directly into the joint


  •          you should not take this product if you have had any previous allergic reactions to Hyalgan or similar material.
  •          You should not have an injection into the knee if you have infections or skin diseases around the injection site.
  •          You should inform the physician if you are allergic to products from birds such as feathers, eggs, and poultry.


side effects are sometimes seen when Hyalgan is injected into the knee joint. These can include:

  •          Local signs and symptoms such as pain, swelling/effusion, heat, or redness at the injection site. Usually such symptoms disappear within a few days by resting the joint and applying ice locally. Only rarely have these events spin more severe and longer-lasting.
  •          Very rare cases of joint infection have been reported. That is why we follow a strictly aseptic technique when administering Hyalgan.
  •          Signs and symptoms of an allergic reaction have been reported. These may include rash, itching, hives, flushing, swelling of the face, tongue, or throat; difficulty breathing or swallowing; shortness of breath.


     Please avoid activities such as jogging, tennis, heavy lifting, or standing on your feet for a long time for the next 48 hours.